Transthyretin (Wild Type) (1.0mg) Cynomolgus Monkey (Macaca fascicularis), Recombinant

Description

Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver, and kidney. The wild type form of TTR is associated with a late onset amyloidosis denoted senile systemic amyloidosis, affecting around 25% of the population above 80 years of age with depositions mainly found in the heart.

Amount

1.0 mg

Format

Lyophilized

Molecular Weight

13705.34 Da

Sequence

GPTGVDESKCPLMVKVLDAVRGSPAVNVAVNVFKKAADETWAPFASGKTSESGELHGLTTEE
EFVEGIYKVEIDTKSYWKSLGISPFHEHAEVVFTANDSGPRHYTIAALLSPYSYSTTAVVTNPKE

Purity

95% by Chromatography and SDS-PAGE

Counter Ion

Ammonium Carbonate

Solubility

The lyophilized protein is readily soluble in PBS pH 7.4.

Storage

Store at -20°C upon arrival.

Source

Protein expressed in Escherichia coli.