Tau PHFcore (306-378) (100 ug) Human, Recombinant

Description

Tau aggregates are a defining hallmark of several neurodegenerative disorders collectively termed tauopathies, including Alzheimer’s disease and frontotemporal dementia, where intracellular inclusions are associated with progressive neuronal dysfunction and degeneration.

Tau 306–378, also referred to as the PHF core, is a truncated fragment of the microtubule-associated protein tau corresponding to residues 306–378 of the human tau sequence. This region comprises the core amyloid-forming segment found within paired helical filaments, including aggregation-prone motifs that are central to tau self-assembly into fibrillar structures. Due to its direct relevance to the structural core of pathological tau filaments, Tau 306–378 is commonly used as a model fragment for studying tau fibrillization, filament formation, and tau-related neurodegenerative pathology.

Amount

100 ug

Format

Lyophilized

Molecular Weight

7924.12 Da

Sequence

VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF

Purity

95% by Chromatography and SDS-PAGE

Counter Ion

Ammonium Carbonate

Solubility

The lyophilized protein is readily soluble in PBS pH 7.4.

Storage

Store at -20°C upon arrival.

Source

Protein expressed in Escherichia coli.