Tau K18 (244-372) (100 ug) Human, Recombinant

Description

Tau aggregates are a defining hallmark of several neurodegenerative disorders collectively termed tauopathies, including Alzheimer’s disease and frontotemporal dementia, where intracellular inclusions are associated with progressive neuronal dysfunction and degeneration.

Tau K18 (244–372) is a truncated fragment of the microtubule-associated protein tau, corresponding to residues 244–372 of the human tau sequence. This fragment contains the four microtubule-binding repeat domains of 4R tau, including the aggregation-prone hexapeptide motifs that drive tau self-assembly into fibrillar structures. Due to its high aggregation propensity and relevance to pathological tau assembly, Tau K18 is widely used as a model fragment for studying tau fibrillization, aggregation mechanisms, and tau-related neurodegenerative pathology.

Amount

100 ug

Format

Lyophilized

Molecular Weight

13682.73 Da

Sequence

QTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIE

Purity

95% by Chromatography and SDS-PAGE

Counter Ion

Ammonium Carbonate

Solubility

The lyophilized protein is readily soluble in PBS pH 7.4.

Storage

Store at -20°C upon arrival.

Source

Protein expressed in Escherichia coli.