Tau dGAE (297-391) (100 ug) Human, Recombinant

Description

Tau aggregates are a defining hallmark of several neurodegenerative disorders collectively termed tauopathies, including Alzheimer’s disease and frontotemporal dementia, where intracellular inclusions are associated with progressive neuronal dysfunction and degeneration.

Tau dGAE (297–391) is a truncated fragment of the microtubule-associated protein tau, corresponding to residues 297–391 of the human tau sequence. This region contains part of the microtubule-binding repeat domain, including aggregation-prone motifs that are important for tau self-assembly into fibrillar structures. Due to its strong tendency to aggregate, Tau dGAE is commonly used as a model fragment for studying tau fibrillization, aggregation mechanisms, and tau-related neurodegenerative pathology.

Amount

100 ug

Format

Lyophilized

Molecular Weight

10165.57 Da

Sequence

IKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAE

Purity

95% by Chromatography and SDS-PAGE

Counter Ion

Ammonium Carbonate

Solubility

The lyophilized protein is readily soluble in PBS pH 7.4.

Storage

Store at -20°C upon arrival.

Source

Protein expressed in Escherichia coli.