Tau 441 (2N4R) (100 ug) Human, Recombinant

Description

Tau aggregates are a defining hallmark of several neurodegenerative disorders collectively termed tauopathies, including Alzheimer’s disease and frontotemporal dementia, where intracellular inclusions are associated with progressive neuronal dysfunction and degeneration.

Tau 441 (2N4R) is the longest adult human isoform of the microtubule-associated protein tau, comprising 441 amino acids generated by alternative splicing of the MAPT gene. In vivo, tau is primarily involved in the stabilization and assembly of neuronal microtubules, thereby supporting axonal transport and maintaining cytoskeletal integrity. The 2N4R isoform contains two N-terminal inserts and four microtubule-binding repeat domains.

Amount

100 ug

Format

Lyophilized

Molecular Weight

45849.91 Da

Sequence

MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDA
KSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGT
GSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPG
TPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGK
VQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSS
TGSIDMVDSPQLATLADEVSASLAKQGL

Purity

95% by Chromatography and SDS-PAGE

QC Data

SDS-PAGE (Coomassie)
- Single band at ~46 kDa
- >95% purity

Mass Spectrometry
- Observed mass: 45846.93 Da
- Theoretical mass: 45849.91 Da

Note: The images and data shown represent a typical QC batch and may not correspond to the current lot.

Counter Ion

Ammonium Carbonate

Solubility

The lyophilized protein is readily soluble in PBS pH 7.4.

Storage

Store at -20°C upon arrival.

Source

Protein expressed in Escherichia coli.