Description
Article no.: AS13 2718B
Product Information
|
Immunogen |
Synthetic peptide derived from human Alpha-Synuclein, amino acids 111-125. |
|
Host |
Mouse |
|
Clonality |
Monoclonal |
|
Subclass/isotype |
IgG1 |
|
Purity |
Affinity purified |
|
Format |
Lyophilized |
|
Quantity |
50 µg |
|
Reconstitution |
For reconstitution add 50 µl of sterile water. |
|
Storage |
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes. |
|
Tested applications |
ELISA (ELISA) |
|
Recommended Dilution |
2-4 ug/ml (ELISA) |
|
Expected | apparent MW |
14 kDa |
Reactivity
|
Confirmed Reactivity |
Human |
|
Not reactive in |
No confirmed exceptions from predicted reactivity are currently known. |
Additional Information
|
Additional information |
The antibody is biotinylated |
Related Products
|
Related products |
Background
|
Background |
Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed. |
Product Citations
|
Product citations |
Brännström et al. (2014). A Generic Method for Design of Oligomer-Specific Antibodies. PLoS ONE. DOI: 10.1371/journal.pone.0090857. |