Anti-Alpha-Synuclein, ASyO2-Biotinylated, Mouse, Monoclonal, Oligomer specific

Immunogen

Synthetic peptide derived from human Alpha-Synuclein, amino acids 131-140.

Host

Mouse

Clonality

Monoclonal

Subclass/isotype

IgG1

Purity

Affinity purified

Format

Lyophilized

Quantity

50 µg

Reconstitution

For reconstitution add 50 µl of sterile water.

Storage

For short time storage add sodium azide and store at +4°C.
For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Tested applications

ELISA (ELISA)

Recommended Dilution

2-4 ug/ml (ELISA capture)

Expected | apparent MW

14 kDa

Confirmed Reactivity

Human

Not reactive in

No confirmed exceptions from predicted reactivity are currently known.

Additional information

This antibody is specific for Human Alpha-Synuclein oligomer structure. The antibody is biotinylated.

Related products

Available antibodies targeting Alpha-Synuclein

Background

Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.

Product citations

Brännström et al. (2014). A Generic Method for Design of Oligomer-Specific Antibodies. PLoS ONE. DOI: 10.1371/journal.pone.0090857.