Transthyretin (L55P) (1.0 mg) Human, Recombinant

Description

Transthyretin (TTR), formerly known as prealbumin, is in vivo involved in the binding and transportation of the thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial Amyloidotic Polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver and kidneys. TTR L55P is associated with a rare and highly aggressive form of FAP.

Amount

1mg

Format

Lyophilized

Molecular Weight

13745 Da

Sequence

GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSES
GEPHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRY
TIAALLSPYSYSTTAVVTNPKE

Purity

95% by Chromatography and SDS-PAGE

QC Data

SDS-PAGE (Coomassie)
- Single band at ~14 kDa
- >95% purity

Mass Spectrometry
- Observed mass: 13745.6 Da
- Theoretical mass: 13745.36 Da

Note: The images and data shown represent a typical QC batch and may not correspond to the current lot.

Counter Ion

Ammonium Carbonate

Solubility

The lyophilized protein is readily soluble in PBS pH 7.4.

Storage

Store at -20°C upon arrival.

Source

Protein expressed in Escherichia coli.