Transthyretin 1-48 fragment (0.1 mg) Human, Recombinant

Description

Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver, and kidney. The wild type form of TTR is associated with a late onset amyloidosis denoted senile systemic amyloidosis, affecting around 25% of the population above 80 years of age with depositions mainly found in the heart.

Amount

0.1 mg

Format

Lyophilized

Molecular Weight

5011.75 Da

Sequence

GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGK

Purity

95% by Chromatography and SDS-PAGE

QC Data

 

SDS-PAGE (Coomassie)
- Single band at ~14 kDa
- >95% purity

Mass Spectrometry
- Observed mass: 5011.40 Da
- Theoretical mass: 5011.75 Da

Note: The images and data shown represent a typical QC batch and may not correspond to the current lot.

Counter Ion

Ammonium Carbonate

Solubility

The lyophilized protein is readily soluble in PBS pH 7.4.

Storage

Store at -20°C upon arrival.

Source

Protein expressed in Escherichia coli.