Alpha-Synuclein (Wild Type) (1.0 mg) Human, Recombinant

Description

Recombinant Alpha-Synuclein Protein

Amount

1mg

Format

Lyophilized

Molecular Weight

14460.16 Da

Sequence

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVAT
VAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQ
EGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

Purity

95% by Chromatography and SDS-PAGE

QC Data

SDS-PAGE (Coomassie)
- Single band at ~14 kDa
- >95% purity

Mass Spectrometry
- Observed mass: 14460.71 Da
- Theoretical mass: 14460.16 Da

Note: The images and data shown represent a typical QC batch and may not correspond to the current lot.

Counter Ion

Ammonium Carbonate

Solubility

Alpha-Synuclein is readily soluble in PBS

Storage

Store at -20°C upon arrival.

Source

Protein expressed in Escherichia coli.

Product Citations

Temsamani, H., Krisa, S., Decossas-Mendoza, M., Lambert, O., Mérillon, J. M., & Richard, T. (2016). Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity. Nutrients, 8(6), 367. doi:10.3390/nu8060367

Brännström, K., Lindhagen-Persson, M., Gharibyan, A. L., Iakovleva, I., Vestling, M., Sellin, M. E., … Olofsson, A. (2014). A generic method for design of oligomer-specific antibodies. PloS one, 9(3), e90857. doi:10.1371/journal.pone.0090857

Sardar Sinha, M., Villamil Giraldo, A. M., Öllinger, K., Hallbeck, M., & Civitelli, L. (2018). Lipid vesicles affect the aggregation of 4-hydroxy-2-nonenal-modified α-synuclein oligomers. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864(9), 3060–3068. https://doi.org/10.1016/j.bbadis.2018.06.020