Product type: Protein
Product name: Transthyretin, (F87M/L110M), Human, Recombinant
Description: Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver, and kidney. The wild type form of TTR is associated with a late onset amyloidosis denoted senile systemic amyloidosis, affecting around 10% of the population above 80 years of age with depositions mainly found in the heart.
F87M/L110M TTR is an engineered variant with monomeric and nonamyloidogenic properties.
Molecular weight: 13,7 kDa
Counter ion: Ammonium Carbonate
Purity: >95% HPLC and SDS-PAGE