Product type: Truncated protein, Methionine in -1 position.
Product name: Apolipoprotein E4, (ApoE4) 1-199 Human Recombinant
Description: Apolipoprotein E is part of the chylomicron and Intermediate-density lipoproteins essential for the normal processing of triglyceride-rich lipoproteins. ApoE is primarily produced by the liver and macrophages. In the central nervous system, ApoE is mainly produced by astrocytes, and transports cholesterol to neurons via ApoE receptors. ApoE. Deposition of amyloid-β (Aβ) in Alzheimer's disease is strongly correlated with the APOE genotype. ApoE has been found to alter the fibrillar growth of Aβ. ApoE display similar properties regarding its effect on Aβ fibril formation in both presence and absence of lipids .
Molecular weight: 2.29 kDa
Counter ion: Ammonium Carbonate
Purity: 95% HPLC and SDS-PAGE
Sequence: MKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQ VTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLA